Joker has Jonny drive him back to the strip club Grin and Bare It where he picks up his love Harley Quinn and has his old second-in-command skinned alive. Promoting Jonny Frost as his new number two, Joker takes Jonny to go and attempt to re-claim the city for his own.

At first the life is nothing but thrills for Jonny. Recruiting Killer Croc as the muscle of the group and Penguin to handle the money transactions, Joker seems to be on the fast track back to the top. There's only one obstacle in his way - Harvey Dent. With his hands in just about every action going on in Gotham, Two-Face has assumed the role of kingpin while also seemingly maintaining his double life as Harvey Dent. Dent calls for a secret meeting with Frost where he tells him that one day Joker will betray him just like he had done the previous second in command. Jonny, always believing it's better to burn out than fade away - knows that he would rather destroy himself than see someone double-cross him and decides to stick with the Joker despite Dent's arguments otherwise.

After being ambushed by a group of off-duty police officers looking to kill him, Joker decides to call a meeting between himself and Two-Face. There he threatens to expose the fact that Two-Face not only has two lives - but two different wives, one for each persona. Dent however has a trick up his own sleeve as he reveals his secret meeting with Jonny and is also holding Jonny's wife hostage. Luckily for Joker, Harley has been hiding nearby with a gun and she pops up and take out Two-Face's guards. Before leaving, Joker threatens to destroy one or both of Two-Face's personas leaving the dual minded criminal to turn to his last resort - the Batman.

Upon rescuing Jonny's wife, Joker sends her away with a bunch of cash in her pocket and proceeds to go out on a killing spree with Jonny. After robbing a liquor store, Joker breaks into the home of an elderly couple and murders them with a switch blade while they lay in their bed at night. The bloody murders are starting to get to Frost and things only appear to be getting worse when they return to their hideout to find that Batman has already taken Croc out of commission.

Joker flees from the Batman before eventually taking Jonny hostage. When Batman moves in to make his attack Joker pulls the trigger and shoots Jonny Frost through the throat. As the Dark Knight and the Joker continue to do battle behind him, Jonny crawls his way towards the ledge of the overpass. He comes to the realization that there is no "cure" for the Joker - the Joker is like the disease that first created Gotham and will be around forever. The only thing that can stop the Joker is Batman himself. Understanding this, Jonny brings himself to the ledge and presumably throws himself off to avoid being taken in.

NOTE:
This is most definitely an Elseworlds title despite not being labeled as such on the cover.