The super-sonic impact of Superman's arrival has unearthed Darkseid's Command-D bunker. The fallen New God stands before the Kryptonian hero underneath a blood red sky as onlookers begin to gather around them. But as Darkseid's Anti-Life Equation has allowed him to infiltrate the minds of nearly every human, the onlookers that Superman once swore to protect are now his enemy. Unwilling to hurt the human beings, Superman soon finds himself at the bottom of a dog-pile, restrained by countless brainwashed citizens and forced to watch as Darkseid fires the Radion bullet backwards in time. The bullet, flying through time-space towards Orion, is now lodged in Darkseid's shoulder and is slowly killing the New God. And death, as Darkseid is about to find out, comes for us all.

Approaching Super Luminal Velocity, Barry Allen and Wally West are racing with Death itself - the Black Racer - hot on their heels. But as they reach their terminal moment, they vibrate through Darkseid, leaving the dragon god squarely in the sights of the Black Racer's Omega Finder Beams. The Racer's scythe-like spear crashes through Darkseid and the used up human-sized husk that was once Dan "Terrible" Turpin falls to its knees.

As if on queue, Wonder Woman arrives with the "armies of Libra" by her side ready to attack Superman. Unfortunately, the Anti-Life infected Amazon does not anticipate the fact that Libra's army is now under the joint control of Lex Luthor and Dr. Sivana. Superman looks on with a stoic expression on his face as a grinning Luthor agrees to a temporary truce between himself and the Man of Steel and sics his army of mind-controlled super villains on Darkseid's Female Furies.

The villains, having been inoculated against the Meta power stripping Morticoccus God-Bacterium upon joining Libra's army, are able to take down the Furies with the help of Supergirl. At just that moment, Frankenstein (naturally immune to the Morticoccus being that he is a walking corpse) rides in on a giant pony hound, grabbing Wonder Woman in it's jaws and causing the mind-control face mask to come off. Free of the clutches of the Anti-Life, Wonder Woman proceeds to bind Darkseid's body with her magic Lasso of truth and wipe his slaves' minds of the Anti-Life influence.

Although humanity is now free of Darkseid, the damage it appears has been done. Miles above them, the Justice League Sattelite is running on nearly zero oxygen. Floating in the near freezing zero-gravity observation deck, Black Canary is pleased to look out on Earth and see the Ray's flight path making the symbol of Metron - signifying humanity's victory.

Elsewhere at Checkmate Castle, Darkseid's storm troopers, still enslaved by their Justifier helmets, continue to do battle with the Mr. Terrific's OMACs and the Biomac armies. It is around this time that Earth-5's Captain Marvel arrives with the others on his quest to gather a Multiversal army of Superman archetypes. Overman, one of those previously recruited, finally finds his beloved cousin Overgirl - only to watch helplessly as she dies in his arms during the siege. Making matters worse, the Lord Eye program is not equip to deal with the stresses caused by Earth-Zero falling into the Abyss. The Black Gambit Inter-brane Escape Tunnel begins losing integrity, threatening to collapse like the Red Sea on the humans fleeing through it.

Unwilling to stand by and allow countless lives to be lost, Hawkman jumps in to battle followed by his re-incarnated love Hawkgirl. The two are caught in the ensuing explosion of Lord Eye and a bright light encapsulates everything around them. Luckily at the moment of Earth's fall and the tunnel's collapse, Mister Miracle's Motherboxxx opened up an emergency Boom-Tube transporting all those present to nearby Earth-51. With everyone safely on Earth-51, Renée Montoya begins her duties as a Global Peace Agent, boarding the Ultima Thule and joining Captain Marvel as he continues his quest.

Before Earth-0 is completely slips into nothingness, Superman and the remaining heroes pool together their resources and create one final Watchtower. An amalgamation of different technologies and structures, the final outpost launches into the void of existence that has now completely become one with Darkseid. The base, floating through the murky blood red void, is where Superman sets about creating the Miracle Machine from his memory of the brief glimpse he was given of it in the 31st Century. Sitting in Metron's chair, he begins drafting the machine. He also begins shrinking down and cryogenically freezing every human being and storing them in ice trays to be thawed out and restored if and when things return to normal.

Facing the end of life itself, they had constructed within the Watchtower a museum-like trophy room full of memorabilia pertaining to the super-hero community - Batman's cowl, Hawkman's head plate and even the giant penny from the Bat-Cave all fill the cavernous structure. In addition, Lois, Jimmy and the others prepare a rocket ship much like the one that first brought Superman to Earth many years ago. Inside they store artifacts from their lives and the final issue of the Daily Planet - detailing man's last stand against evil and how Batman, in his final moments - had mortally wounded the God of all Evil. They launch the rocket with hopes that somewhere in some time may hear of their adventures - the Monitors' "germ" creatures making one final attempt to spread their narrative disease.

A fragment of Earth-44 crashes into the Watchtower as it too hurdles through the nothingness of Darkseid, bringing the Metal Men with it. Once aboard the Metal Men begin to malfunction and threaten to commit technocide. Supergirl leaves to check on the status of the problem which leaves Superman alone with his partially constructed Miracle Machine. Darkseid, his human body long since becoming useless and immobile, has manifested himself in true god form - a nearly awe inspiring whirl of lights and images from which the booming voice of Darkseid emanates. Darkseid taunts Superman's almost primitive comprehension of the god machinery he is constructing and the regard with which he holds it.

Superman knows that the worlds of the Multiverse which Darkseid has nearly devoured whole all vibrate together making a sound like a beautiful orchestra - the music of the spheres. Wanting to be rid of the evil god once and for all - Superman uses every ounce of strength within his vocal cords to shout a discordant melody of counter-vibrations that cancel Darkseid out killing him and effectively terminating the whole of existence and plunging everything into complete darkness.

The Watchtower destroyed, Superman is seemingly the only thing left standing. Mute and nearly defeated he is left alone in the deafening silence of the void. It's in this silence that Superman begins to notice a sound that even his super-hearing had never been able to pick up on before then - a heartbeat. He traces the silent noise to it's point of origin - Metron's chair. Prying open the Fallen God's chair he finds within it Element X - the final component necessary for powering up the Miracle Machine. But with it is not only silence that accompanies the empty void as Mandrakk, re-born within the shell of the fallen Monitor Rox Ogama, creeps out of the shadows.

He and his follower the vampire Ultraman stalk towards Superman with his cousin Supergirl in tow. Superman is barely distracted by their taunts however as he powers up the Machine which was once said to be "like a cell phone to the gods" - capable of calculating the Life Equation itself. The device summons the Multiversal Monitor Nix Uotan and heralds the arrival of Captain Marvel's squad of Supermen. They along with the vengeful angels of the Pax Dei and Zoo Crew surround Mandrakk and Ultraman and rally their forces together against their evil presence.

The team of Supermen, powered by the energy of 52 sons, focus their combined heat vision on the two evil-doers, igniting them into flames. The Green Lanterns, their rings almost out of juice as the final seconds of their 24 hour window tick away, merge their power streams into one glowing green stake to pierce the heart of the celestial vampire Mandrakk. Looking down upon the charred remains of Ultraman and the Dark Monitor, Nix Uotan states "The Multiverse has natural defenses none of you could have imagined. No one %$%$ with the judge of all evil."

Following Mandrakk's defeat, Nix Uotan overseas the reconstruction of Earth-0 as the multiversal teaming of Supermen and Green Lanterns help pull the Earth from out of the black hole that Darkseid's fall plunged it into. Back on Earth, the people, the "germs" the Monitors once looked so condescendingly upon prove how marvelous they really are, rebuilding their lives just as they always have when faced with such devastation.

At his final debriefing in front of the Monitor counsel, Nix Uotan explains the black hole at the base of creation as being the site where Darkseid fell through existence to his doom - leaving Hell (Apokolips) deserted. He also goes into detail of how Earth Designate 51 was reconstructed, restoring the harmony that was once disrupted by Rox Ogama. It is there, on Earth-51, that New Genesis was born anew from the ashes of Apokolips and the once desolate Earth was christened as the new home of not only the New Gods re-incarnate but also Kamandi and the Tiger Army.

Because they had nearly destroyed the beautiful organic worlds of the Orrery by their interference, Nix Uotan calls for the withdrawal of all Monitor oversight. The Monitor world begins to dismantle itself as they surrender themselves over to the searing emptiness of the Overvoid. Nix Uotan and Weeja Dell have one final meeting in which Nix Uotan promises to once again never forget the love that brought him back to power and triggered his re-ascension to Monitor Status.

The world crumbles and fades away and the next thing Nix Uotan knows he is waking up once again in human form. The newscaster on the television is talking about how the recent discovery of the parallel worlds of the Multiverse could change all of their lives....

Millions of years in the past, the first boy, the warrior Anthro is now an old man. He lays down next to the fire he created, a gift first imparted by the gods - and it's there that he passes away of old age, the symbol of Metron still painted upon his face and on the cave wall above him. Nearby however, the rocket ship filled with Earth-0's futuristic artifacts had crash landed on the primitive shores. A man bearing a striking resemblance to Bruce Wayne, wearing the bottom half of the Batman outfit, begins a new sketching an addition to Anthro's artwork on the cave wall - the symbol of a Bat....